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While the intervention with both doses of desloratadine was effective in terms of a reduction in hyperthermic skin area, there was no improvement in wheal area and wheal volume compared with no treatment.

Wheal numbers were reduced after treatment with 20 mg, but not 5 mg, desloratadine.

Recovery time was slightly longer in group KP compared with group FP (11.19 ± 2.59 min and 9.43 ± 1.23 min, respectively), time needed to achieve Aldrete Recovery Scale Score of 9 was comparable in both groups, and sedation-related side effects as hypotension, bradycardia, apnea, and reduction of Sp O were more significant in the FP group.

It is characterized by a recurrent and spontaneous appearance of itchy wheals with or without angioedema, for 6 weeks or longer (1, 2).

That said, in overdose selectivity is lost and patients can develop increased sedation, anticholinergic effects and hypotension.

QT prolongation occurs secondary to potassium channel blockade.

Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.

In common use, the term "antihistamine" refers only to H In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.

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